Mastering the Evolving Treatment Landscape in HER2-Positive Breast Cancer: Final Assessment

Launch Date:
May 25, 2022

Primary Audience:

Medical oncologists, Nurses, Nurse Practitioners, Pharmacists

Relevant Terms:

Breast cancer, HER2-positive breast cancer, Brain metastases, CNS metastases

Now that you have learned more about the management of HER2+ breast cancer, we ask you to please revisit the questions you addressed at the start of this program.

Aditya Bardia, MD, MPH

Associate Professor, Medicine
Harvard Medical School
Attending Physician, Medical Oncology
Massachusetts General Hospital
Boston, Massachusetts

Dr. Aditya Bardia is an Associate Professor in the Medicine Department at Harvard Medical School and Attending Physician at Massachusetts General Hospital Cancer Center, Boston, Massachusetts. He is the Director of Breast Cancer Research in Medical Oncology at Massachusetts General Hospital. He has led several high-impact clinical trials investigating novel therapies and translational studies in breast cancer including lead of the clinical development of the antibody drug conjugate, sacituzumab govitecan, now FDA-approved for triple-negative breast cancer. He is the author of more than 150 peer-reviewed papers. He is the recipient of Young Investigator Award from the ASCO Conquer Cancer Foundation and Career Catalyst Award for Susan G. Komen Foundation. Dr. Bardia is a faculty member of molecular tumor board by ASCO University and receipt of FASCO.

Claudine Isaacs, MD

Professor of Medicine and Oncology
Associate Director for Clinical Research
Georgetown University
Washington, DC

Dr. Claudine Isaacs is a Professor of Medicine and Oncology, Associate Director for Clinical Research and Leader of the Clinical Breast Cancer Program at the Lombardi Comprehensive Cancer Center (LCCC) at Georgetown University.  She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research.  She has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer and currently serves as Co-Chair Endocrine Resistance Working Group of the Translational Breast Cancer Research Consortium (TBCRC) and as Co-Chair of the Clinical Trials Operations Working Group for the I-SPY 2 Trial. She has authored over 200 peer-reviewed publications and edited two textbooks. She has served on a number of national committees including the Scientific Program Committees at ASCO, the ASCO Breast Cancer Guideline Advisory Group, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the NCI.
1.
Integrate recent advances and available clinical data to optimally sequence HER2-targeted agents in the treatment of HER2-positive breast cancer from early stage through multiple lines of treatment for MBC
2.
Discuss with patients the relative value of different adjuvant and extended adjuvant approaches with sensitivity for the patient’s preferences and risk of progression
3.
Plan effective therapy for patients with HER2-positive MBC with or without CNS metastases incorporating existing and emerging targeted treatments
4.
Describe the mechanism of action, efficacy results, and toxicity profile of the most newly approved and promising investigational HER2-targeting agents
5.
Assess ongoing clinical research studies evaluating novel agents and treatment strategies under development for HER2-positive breast cancer